A U S T I N H O S P I T A L A N D R E P A T R I A T I O N G E N E R A L H O S P I T A L Chairman o f department: Professor A . E. Doyle
Professor AUSTIN ERIC DOYLE
Professor (Repatriation General Hospital) THOMAS JOHN MARTIN Professor of Clinical Pharmacology and Therapeutics W I L L I A M JOHN LOUIS Reader I A N FARQUHAR CAMPBELL McKENZIE
Reader in Psychiatry RUSSELL A1NSL1E MEARES
First Assistant (Austin Hospital) FREDERICK ARTHUR OSCAR MENDELSOHN First Assistant (Repatriation General Hospital) RICHARD GRAEME LARKINS Second Assistants NEVILLE DAVID YEOMANS
JAMES SAVILLE WILEY
Second Assistant in Psychological Medicine (Repatriation General Hospital) PAUL EDWARD DEBENH AM Senior Lecturer in Clinical Pharmacology and Therapeutics BEVYN JARROTT
Lecturer in Psychiatry BRUCE JOHN TONGE
Senior Research Officer in Clinical Pharmacology and Therapeutics PHILIP MARK BEART National Health and Medical Research Council Senior Research Officer JEANNETTE FRIEDMAN National Heart Foundation of Australia Research Fellow SADANAND NEGESHRAO ANAVEKAR National Health and Medical Research Council Postgraduate Research Scholars
NICHOLAS CHRISTOPHIDIS PETER JOHN MIACH
National Blood Pressure Study Research Fellow MARY STEWART
Visiting Research Fellow in Clinical Pharmacology and Therapeutics ROGER JAMES SUMMERS Postgraduate Research Scholars ANDREW BUI
OLAF HE1NO OSKAR DRUMMER STUART GRANT DUFFY ANDREW SIMON GIRAUD PHILLIP MARK HOGARTH BRUCE EDWARD LOVELAND MARY M1CHAEL1DES GEORGE W I L L I A M MIHALY G I L L I A M MARGARET MORGAN TERRANCE A D R I A N POTTER A L A N GREGORY RIGLAR MAURO SERGIO SANDRIN ELIZABETH LYN CONWAY A N N E JULIA CULVENOR ARLIE McQUEEN
Trainee Fellow in Gastroenterology RICHARD BLAMIRE SEWELL Professorial Associates PETER FRANCIS BLADIN
PETER ANTHONY CASTALDI JOHN KINGSLEY DAWBORN RICHARD A L A N SMALLWOOD
Senior Associate in Social Medicine DAVID GEORGE LEGGE Senior Associates (Austin Hospital) JOHN PAUL COGHLAN
A L A N JAMES GOBLE WALTER FRANCIS HEALE GEORGE JERUMS
ROBIN MACINTOSH LATHROP MURRAY MARY ROSE STEWART
FRANK JOHN EMERY VAJDA
Senior Associates (Repatriation General Hospital) W I L L I A M ROBERT ADAM COLIN EDWIN BARTER
ALAISTAIR HERIOT CAMPBELL JOHN GREEN
JOHN DESMOND PARKIN
Associates (Austin Hospital) JOHN COURTNEY DUGGAN
R E S E A R C H T O P I C S IN P R O G R E S S (Medicine — Austin Hospital) 1. Investigation ot the local role of the renin angiotensin system in the kidney.
2. Control of aldosterone secretion from isolated zona glomerulosa cells.
3. Radio nucleotide detection of experimental cortid ulceration.
4. Handling of drugs and protein metabolites in renal failure.
118
MEDICINE 119 5. A study of 'H-ouabain binding to normal and leukaemic lymphocytes.
6. Platelet sizing by measurement of intracellular water content.
7. Evolution of trace proteinuria in diabetes mellitus.
8. Effects of thyroid status on lymphocyte Na-K ATPase.
9. Comparative structural and functional studies of the gastric mucosa of chordates.
10. The mucoid cells in the gastric mucosa: their role in gastric physiology and pathophysiology.
11. Studies of the mechanism of the peptic ulcerogenic effects of tabacco smoking.
12. Transport and excretory function of the foetal liver.
13. Bile acid transport. Its relationship to bile acid structure and biliary lipid composition.
14. Platelet membrane proteins in coagulation.
15. Lymphocyte surface alloantigens.
16. H-2 mutants.
17. The H-2 complex in transplantation tolerance and enhancement.
18. The human Ia System.
19. Ia+cells in mouse bone marrow.
20. The padrenergic receptor of murine lymphocytes.
21. Methods of detection of circulating immune complexes in man.
(Medicine — Repatriation General Hospital)
1. Hormones and guanyl nucleotides in the regulation of adenylate cyclase in normal and tumour cells.
2. Prostaglandins in the pathogenesis of malignant hypercalcaemia.
3. Role of prostocyclin and thromboxanes in platelet-vessel wall interaction.
4. Secretion and action of vitamin D metabolites.
5. Regulation of insulin secretion.
6. Pathogenesis of Paget's Disease and of renal bone disease.
(Clinical Pharmacology and Therapeutics) 1. Thc role of central nervous system-transmitters and blood pressure regulation.
2. Specific labelling and isolation of cardiac beta adreno-receptors using radioactive photo affinity agents.
3. Structure activity relationship of beta adreno-receptor drugs and the relationship of alterations of beta adreno-receptors to disease states.
4. Vascular cyclic AMP and blood pressure regulation.
5. Pharmacokinetics of anti-cancer drugs.
6. Amino acid transmitters in central nervous system diseases.
7. Pharmacokinetics and clinical evaluation of anti-hypertensive drugs.
8. Pharmacokinetics and clinical evaluation of anti-epileptic drugs.
9. Mechanisms of action of methyldopa.
10. Control of noradrenaline synthesis.
(Psychiatry)
1. Post-natal depression and its effects on attachment and child development.
2. Emotional disturbance in the physically ill hospitalized child.
3. Outcome studies of group play psychotherapy for latency age children.
4. A study of sensory screening and its relation to personality.
5. Stimulus intensity control in personality.
6. Stimulus intensity control in hysteria and psychogenic pain.
7. Stimulus intensity control in anxiety states, and the effect of treatment.
8. Stimulus intensity control of depression, and the effect of treatment.
9. Psychophysiology of the menstrual cycle.
10. Pschopnysiological effects of tobacco smoking.
11. Stimulus intensity control and tobacco smoking.
12. Repression and hypertension.
13. The circannial variation in suicide rates and attempted suicide.
14. A study of temporal patterns of gaze and vocalization in mother-child interaction.
15. A longitudinal study of mother-child interaction and its relation to attachment.
16. Some physiological changes occurring during mother-child interaction.
17. Attachment in children referred for "Hyperactivity"
18. Cortical evoked potentials in hyperactive children.
19. Naturopathic treatment in hyperactivity in children.
20. Attention in hysteria.
PUBLISHED WORK BOOK
CHAPTERS IN BOOKS
1. LIPTON, G. L. and TONGE, B. J. — The essence of Mothering Children under Five, in Modern Perspectives in the Psychiatry o f Infancy, ed. J. G. Howells, Brunner/Mazel Inc., New York.
ENCYCLOPAEDIA ARTICLE
1. MEARES, R. A. — Psychiatry in Australia, in International Encyclopaedia of Neurology, Psychiatry, Psychoanalysis and Psychology, ed. B. Wolman, Van Nostrand Reinhold and Aesculapius Publishers, N.Y.
1977.
ARTICLES
1. ATKINS, D , HUNT, N . H., INGLETON, P. N . , UNDERWOOD. J. C. E. and M A R T I N , T. J. - Rat osteogenic sarcoma cells. Isolation and effects of hormones on the production of cyclic AMP and cyclic GMP. Endocrinology, 101: pp. 555-562, 1977.
2. ATKINS, D , IBBOTSON, K. J., HILLIER, K , HUNT, N . H.. HAMMONDS, J. C. and M A R T I N , T. J.
— Renal cortical carcinoma. Secretion of prostaglandins as bone resorbing agents by renal cortical carcinoma in culture. Brit. J. Cancer 36: pp. 601-607, 1977.
3. ATKINS, D. and M A R T I N , T. J. — Rat osteogenic sarcoma cells: effects of some prostaglandins, their metabolites and analogues on cyclic AMP production. Prostaglandins 13: pp. 861-871, 1977.
4. ANAVEKAR, S. N . — Management of acute hypertensive crises. Rational Drug Therapy 11 (8): 1, 1977.
5. ANAVEKAR, S. N. — Propranolol in the management of hypertension. Drug Therapy, Vol 8: pp. 99. 1977.
6. BACQ. A. M , BLAKELEY, A. G. H. and SUMMERS, R. J. - The effects of 1.93494 on adrenergic transmission in the cat spleen. Bri. J. Pharmac. 60: 286P, 1977.
7. BEART, P. M. and BILAL, L. - L.-2,4-diaminobutyric acid and thc GACA system. Neuroscience Letters 5:
pp. 193-198, 1977.
8. BEART, P. M . and LEE, V. — Transmitter enzymes in weaver and staggerer neurological mutant mice.
Brain Res. 124: pp. 171-171, 1977.
9. BEART, P. M. and ROFFLER-TARLOV, S. - GABA synthesis in the Purkinje cell deficient mouse. Proc.
Australian Physiol. Soc. 8 (1): 45P, 1977.
10. BEST, L. C , M A R T I N , T. J , RUSSELL, R. G. G. and PRESTON, F. E. - Prostacyclin (PG) stimulates the accumulation of cyclic AMP and adenylate cyclase activity in human blood platelets. Nature 267:
pp. 850-852. 1977.
11. BEVERLEY, P. C. L , FELDMANN, M , DUNKLEY, M . and McKENZIE, I . F. C. - Antigenic Phenotypes of T Cell subsets. Transplant Proc. 9: 703, 1977.
12. BLADIN, P. F., VAJDA, F. J. E. and SYMINGTON, G. - Therapeutic problems related to tonic status epilepticus. Assoc. Neurologists Proceedings. 1977.
13. BLAKELEY, A. G. H. and SUMMERS, R. J. - The effects of labetalol (AH5258) on adrenergic transmission in the cat spleen. Br. J. Pharmac. 59: pp. 643-650, 1977.
14. BLANDEN, R. V.. McKENZIE, I . F. C , KEES, U., MELVOLD, R. W. and KOHN. H I - Cytotoxic T Cell response to ectromelia virus-infected cells. Different H-2 requirements for triggering precursor T Cell induction or lethal hit by effector T Cells defined byan H-2D°mutation./. Exp. Med. 146: pp. 869-880, 1977.
15. BOYD, H. and M A R T I N , T. J. — The effect of propranolol on induction of rat liver tumours by a chemical carcinogen. Molec. Pharmacol. 13: pp. 576-578, 1977.
16. BOYSE, E. A., CANTOR, H , SHEN, ,F. W. and McKENZIE, I . F. C. - Nomenclature for antigens demonstrable on lymphocytes. Immunogenelics 5: 189, 1977.
17. CALDWELL, A. B. and JARROTT, B. - A photoaffinity probe for the beta adreno-reccptor. Adv. Cyclic Nuc. Res. 9: 75. 1977.
18. CONNELLAN, J. M., CASTALDI, P. A. and MUNTZ, R. H. - The role of factor X I in the coagulant activity of platelets. Haemostasis 6: 41, 1977.
19. CONWAY, E. L„ JARROTT, B. and LOUIS, W. J. - Alpha methyldopaminc as a false transmitter in thc corpus straitum. Clin. Exp. Pharmac. Physiol. 4: pp. 216-217, 1977.
20. CULVENOR, A. J. and JARROTT, B. - Effect of chronic administration of L-a-methyldopa on L- aromatic amino acid decarboxylase in thc rat. Proc. Aust. Phvsiol. Pharmacol. 8: 37P, 1977.
21. DAWBORN, J. K , SEMMENS, K. and STORY, H. F. R. — Urinary tract infection in men. Patient Management. Issue 8. Vol.6: pp.47, 1977.
22. DAWBORN, J. K., MacNEIL, S. and M A R T I N , T. J. - Diuretics and thc renal adenylate cvclase system.
Brit. J. Pharmacol. 61: pp. 657-667, 1977.
23. F E L D M A N N , M . , BEVERLEY, P., ERB, P., HOWIE, S., K O N T I A I N E N , S, MOAZ, A , MATHIES, M , McKENZIE, I . F. C. and WOODY, J. - Current concepts of the antibody response - heterogeneity of lymphoid cells, interactions and factors. 41 si Cold Spring Harbor Symposium 61: 113, 1977.
24. FELDMAN, M . i BEVERLEY, P. B. L , WOODY, J. and McKENZIE, I . F. C. - T-T interaction in the induction of suppressor and helper T Cells. Analysis of membrane phenotvpe of precursor and amplifier cells.
J. Exp. Med. 145: 793, 1977.
25. FREEMAN, M . and TONGE, B. J. - A case study of emotional and cognitive growth. A joint treatment approach, Aust. J. o f Human Comm. Dis. 5: pp. 61-67, 1977.
26. GEFFEN, L. B. and JARROTT, B. - Cellular aspects of catecholaminergic neurons. Handbook o f Physiology, Section 1: The nervous system, pp. 521-571, 1977.
27. GIRAUD, A. S., YEOMANS, N . D. and ST. JOHN, D. J. B. - Comparative ultrastructure and histochemistry of vertebrate gastric mucosa. 1. Reptilia (genus Tiliqua). Clin. Exper. Pharmacol. Phvsiol. 4:
478, 1977.
MEDICINE 121 28. HEYMA, P., LARKINS, R. G.. PERRY-KEENE, D , PETER, C. T , ROSS, D'. and SLOMAN, J. G. -
Thyroid hormone levels and prolein binding in patients on long-term diphenvlhydantoin treatment. Clinical Endocrinology 6: pp. 369-376, 1977.
29. HUNTER, C. R , GIRAUD, A. S. and ST. JOHN, D. J. B. - Surface epithelium cytoarchitecture ofthe proximal gastrointestinal tract in the blue tongue lizard. (Tiliqua scincoides). J. Anlat. 124: 525. 1977.
30. HUNT, N. H.. ELLISON, M . , UNDERWOOD, J. C. E. and MARTIN, T. J. - Calcitonin-responsive adenylate cyclase in a calcitonin-producing human cancer cell line. Brit. J. Cancer 35: pp. 777-784, 1977.
31. INGLETON, P. M . , UNDERWOOD, J. C. E., HUNT, N . H . , A T K I N S , D., GILES, B., COULTON, L. A. and M A R T I N . T. J. — Radiation induced osteogenic sarcoma in the rat as a model of hormone-responsive differentiated cancer. Lab. Animal Sci. 27: pp. 748-756, 1977.
32. JACKSON. D. C , PARISH, C. R. and McKENZIE, 1. F. C. - Detection and isolation of an la glycoprotein antigen from mouse serum. Immunogenetics 4: 267. 1977.
33. JARROTT, B. - Drugs and receptors I . An overview, Clin. Pharm. I : pp. 1-4, 1977.
34. JARROTT, B. — Drugs and receptors I I . The adenyl cyclasc/cyclic AMP system. Clin. Pharm. 2: pp. 5-12, 1977.
35. JARROTT. B. - Drugs and receptors I I I . Acetyl-choline and its receptors, Clin. Pharm. 3: pp. 13-20, 1977.
36. JARROTT,' B. - Drugs and receptors IV. Opiates and their receptors. Clin. Pharm. 4: pp. 21-24, 1977.
37. JARROTT, B. and LOUIS. W. J. - Abnormalities in enzymes involved in catecholamine synthesis and catabolism in phaeochromocytoma. Clin. Schi. Mol. Med. 53: pp. 529-535, 1977.
38. JARROTT, B. and SPECTOR, S. - Development ofa radio immunoassay for clonidine. Fed. Proc. 36: 949, 1977.
39. JONES, E. A , C A I N . G . D , SMALLWOOD, R. A. and ROSENOER. V. M. - Possible adverse effects of corticosteroids on nitrogen metabolism in fulminant hepatic failure. Proceedings of conference on Fulminant Hepatic Failure. N.I.H.. Bethesda, February, 1977, Page 356.
40. LARKINS, R. G. and SIMEONOVA, L. - The relationship between glucose utilization cyclic AMP generation and insulin secretion in C57BI6J and NZO islets. Diabetologia 13: 412, 1977.
41. LARKINS, R. G. - Vitamin D metabolism. Med. J. Aust. 2: pp. 175-176, 1977.
42. LESTER, R , SMALLWOOD, R. A , LITTLE, J. M . , BROWN, A. S., PIASECKI, G. J. and JACKSON, B. T. - Fetal bile salt metabolism. The intestinal absorption of bile salt. J. Clin. Invest. 59:
pp. 1009-1016, 1977.
43. LOUIS, W. J., JARROTT, B., BURNSTOCK, G. and WATANABE, H. - Studies of neurotransmitter release in the pathogenesis of hypertension. Conlr. Nephrol. 8: pp. 182-189. 1977.
44. LOUIS, W. J. and McNEIL, J. J. — The clinical pharmacology and therapeutics of beta-blocking drugs.
Sandoz Therapeutic Quarterly 413: pp. 1-11, 1977.
45. LOUIS, W. J„ McNEIL, J. j . and DRUMMER, O. H. - How safe are beta-blocking drugs. Med.J. Aust.
Special Suppl: 2: pp. 20-24, 1977.
46. MacINTYRE, I . , EVANS, I. M . A. and LARKINS, R. G. - Vitamin D. Clinical Endocrinology 6: pp. 65- 79. 1977.
47. McCLELLAND, M. J , SMALLWOOD, R. A , HOFFMAN. N. E. and HOOGENRAAD, N. J. - Binding of cholic acid to soluble proteins from rat liver. FEBS Letters 82: 2, 1977.
48. McNEIL, J. J.. LOUIS, W. J., VIJAYASEKARAN, V. and VAJDA, F.J. E. - Bioavailability comparison of two generic preparations of Frusemide. Med. J. Aust. 2: 505, 1977.
49. McKENZIE, I . F. C , MORGAN, G. M„ MELVOLD, R. and KOHN, H. I . - H - 2d b mutant which separates H2-Ddinto 2gcncs. Immunogenetics4: 133, 1977.
50. McKENZIE, I. F. C , CLARKE, A. E. and PARISH, C. R. - Ia Antigenic specificities areOligosaccharid in Nature. Hapten Inhibition Studies. J. Exp. Med. 145: 1039, 1977.
51. McKENZIE, 1. F. C , MORGAN, G., MELVOLD, R. and KOHN, H. I . - Studies of H-2 mutations in C57BL/6 and Balb/c. Transplant Proc. 9: 551, 1977.
52. McKENZIE, I . F. C . GARDINER, J , CHERRY, M . and SNELL, G. - Lv lymphocyte antigens Ly-4.
Ly-6 and Ly-7. Transplant Proc. 9: 667, 1977.
53. McKENZIE. I . F. C. and PARISH, C. R. — Detection and characterisation of serum la material in the mouse. Transplant Proc 9: 621, 1977.
54. McKENZIE. I. F. C. and HENNING, M. - Studies of immunogenicity and enhancement of alloantigens of the various regions ofthe H-2 complex. Transplant Proc. 9: 609. 1977.
55. McKENZIE, I. F. C . MORGAN. G , MELVOLD, R. W. and KOHN, H I - Studies on H-2 mutations in C57BL/6 and Balb/c. Folia Biol. 22: pp. 389-390, 1977.
56. McKENZIE, I . F. C. and HENNING, M . - The immunogenicity of alloantigens of thc various regions of the H-2 complex. Folio Biol. 22: 417-418, 1977.
57. McKENZIE. I. F. C. - The HLA system and its relationship to disease. Proc. Aust. Inst. Med. Tech. 1977.
58. McKENZIE, 1. F. C. - Histocompatibility antigens and the immune response. Aust. Blood Transfusion Society. 1977.
59. McKENZIE, I . F. C. and HENNING, M . - The H-2 complex. Immunogenicity and enhancement studies of H-2K region alloantigens. J. Immunogenetics 4: 249, 1977.
60. McKENZIE, I . F. C. and HENNING, M . — The I region transplantation antigens, immunogenicity and enhancement. J. Immunogenetics 4: 259. 1977.
61. McKENZIE, I. F. C , PANG, T. and BLANDEN, R. V. - The use of H-2 mutants as a model for studying T Cell activation. Immunol. Rev. 35: 181, 1977.
62. McKENZIE. I . F. C. and PARISH, C. R. — Detection and characterisation of serum Ia material in the mouse. Folia Biol. 22: 413, 1977.
63. McKENZIE. I. F. C. - Inbred and genetically defined strains of laboratory animals. Section III 37a. b, c.
F.A .S.E.B. Office of Biological Handbooks. 1977.
64. MUNTZ, R. H. and CASTALDI, P. A. - Use of rabbit antisera in the preparation of Factor X I I - free platelet rich and platelet poor plasma. Haemostasis 6: 35, 1977.
65. PARISH, C. R. and McKENZIE, I . F. C. — Mitogens and T-independent antigens stimulate T lymphocytes
66. PARISH. C. R. and McKENZIE, I . F. C. — Direct visualization of T Ivmphocvtes bearing la antigens controlled bv the I-J subregion. J. Exp. Med. 146: 332, 1977.
67. PERRY-KEENE. D. A., ALFORD, F. P., CHISHOLM, D. J , FINDLAY, D. M.. LARKINS. R. G. and M A R T I N . F. I . R. — Glucagon and diabetes I . The failure of hyperglucagonacmia to influence thc response of diabetic keto-acidosis to therapv. Clinical Endocrinology 6: pp. 471-477, 1977.
68. SEWELL, R. B , HOFFMAN, N . E , IRETON, H. J. C and SMALLWOOD, R. A. - Plasma disappearance of intravenously injected radiolabeled glycocholic acid in patients wilh liver disease. Ausi.
N.Z.J. Med. 7: pp. 148-150, 1977.
69. SNOW. D. H. and SUMMERS, R. J. - Thc actions of the beta adrcno-ceptor blocking agents propranolol and mctoprolol in the maximally exercised horse. J. Physiol. 271: pp. 39-40, 1977.
70. SUMMERS, R. J. and JANET T I L L M A N — An investigation of supersensitivity produced by cocaine in isolated strips of cate splenic capsule. Proc. Aust. Phys. Pharmac. 8: 157, 1977.
71. SUMMERS. R. J. and JANET T I L L M A N - The effects of labetalol (AH5I58) on metabolism of !H(-) noradrenaline released from the cal spleen by nerve stimulation. Biochem. Pharmac. 26: pp. 2137-2143, 1977.
72. M A R T I N , T. J. — Mode of action of calcitonin. In "Human calcitonin and Paget's disease". Ed. I . Maclntvre, Hans Huber, Bern. pp. 34-49, 1977.
73. M A R T I N . T. J., JERUMS, G., MELICK, R. A., XIPELL, J. M . and ARNOTT, R. - Clinical, biochemical and histological observations on the effect of porcine calcitonin in Paget's disease of bone. Aust.
N.Z.J. Med. 7: pp. 36-43, 1977.
74. M A R T I N , T. J , HUNT, N . H., ELLISON, M , UNDERWOOD, J. C. E. and MICHEI.ANGELI. V. P.
— Physiology and pharmacology of calcitonin action. Molecular Endocrinology ed. I . Maclntyre and M . Szelke, Elsevier/North Holland Biomedical Press, pp. 179-192. 1977.
75. M A R T I N , T. J. - Secretion of hypothalamic and pituitary hormones by non-endocrine tumours. / Clin.
Path. 7S: pp. 26-30, 1977.
76. MEARES, R. and HOBSON, R. - The persecutory therapist. Brit. J. Med. Psychol. December, 1977.
77. MENDELSOHN, F. A. O. - Intra-renal angiotensin I I during sodium deficiency in the rat. Aust. M.Z.J.
Med 7(2): 206, 1977.
78. MENDELSOHN, F. A . O . - Measurement of intra-renal angiotensin U.Atut. N.Z.J. Med. 7(6): 678, 1977.
79. MENDELSOHN, F. A. O. - Intra-renal angiotensin I I in acute renal failure Aust. N.Z.J. Med. 7(4): 447, 1977.
80. M1HALY, G. W , PHILIPS, J. A., LOUIS, W. J. and VAJDA, J. F. E. - Measurement of carbamazepine and its epoxide metabolite by High-Performance Liquid Chromatograph, and a comparison of assay techniques for the assay of carbamazepine. Clin. Chem. 23: pp. 2283-2287, 1977.
81. VAJDA. F. J. E„ SYMINGTON, G. and BLADIN, P. F. - Rectal administration of sodium valproate.
Lancet fi): pp. 359-360, 1977.
82. WILEY, J. S. and SHALLER, C. C. - Selective loss of calcium permeability on maturation of human reticulocytes. J. Clin. Invest. 59: pp. 1113-1119, 1977.
83. WILEY, J. S. - Genetic abnormalities of cation transport in the human erythrocyte. Membrane transport in red cells. Academic Press {London), pp. 337-361, 1977.
84. WILEY, J. S., KRAFT and COOPER, 1. A. - JH-Ouabain binding sites on normal and leukaemic lymphocytes. Clin. Exp. Pharm. Physiol. 4: 473, 1977.
85. WILEY, J. S., WRAY, G. and COOPER, I . A. - Platelet water content is decreased by gel nitration.
Thrombosis and Haemostasis 38: 214, 1977.
86. WILEY, J. S, KRAFT, N. and COOPER, I . A. 'H-Ouabain binding sites are reduced on chronic leukaemic lymphocytes. (CLL). Proc. Haem. Soc. Aust.. 1977.
87. WOODHOUSE. N. J. Y , MOHAMEDALLY, S. M„ SAED-NAJAD, F. and M A R T I N . T. J. - Development and significance of antibodies lo salmon calcitonin in patients with Paget's disease on long-term treatment. Brit. Med. J. 2: pp. 927-929, 1977.
88. WOODY. J. N„ FELDMANN, M , BEVERLEY, P. C. L. and McKENZIE, I . F. C. - Expression of alloantigens Ly-5 and Ly-6 on cytotoxic effector cells. J. Immunol. 118: 1739. 1977.
89. YEOMANS, N . D. - Cell differentiation in developing fundic mucosa. Aust. N.Z.J. Med. 7: 102. 1977.
90. YEOMANS, N . D. - Differentiation of the mucoid cells in developing gastric antrium. CVin. Exper.
Pharmacol. Physiol. 4: 479, 1977.
T H E S E S P A S S E D F O R H I G H E R D E G R E E S Doctor of Medicine
1. HOFFMAN, N. E. - Bile Acid Physiology
Doctor of Philosophy
1. CALDWELL, A. - Studies Toward the Isolation of the Beta-adreno Receptor
2. FRIEDMAN, J. — Psychopharmacological and Psycho-physiological Studies in Normal Subjects and Psychiatric Patients
T H E S E S IN P R O G R E S S (Medicine — Austin Hospital)
PhD Theses in Progress A. BUI — Volume Regulation by Human Blood Lymphocytes C. F. BUTTIGIEG — Control of Renin Release in vitro
S. DUFFY — Exchangeable Sodium and Experimental Hypertension
MEDICINE 123 A. GIRAUD — A Comparative Study of the Gastric Mucosa in Chordata
M. HOGARTH — The Alloantigens of Murine Tumours
B. LOVELAND — Models of Transplantation Rejection, Enhancement and Tolerance M. MICHAELIDOS — The Alloantigenic Phenotypes of Mitogen Responsive Lvmphocvtes 0. MORGAN - H-Z Mutants
T. POTTER — Lvmphocvte Surface Alloantigens M. SANDRIN -' The Human la System
BSc (Hons) Thesis in Progress
C. THOMSON — Identification of the cell mediating suppression of delayed type hypersensitivity in mice MSc Thesis in Progress
A. RIGLAR — Methods of Detection of Circulating Immune Complexes in Man MD Theses in Progress
A. MARSHALL — Hepatic Transport of Drugs R. SEWELL - Ontogenesis of Bile Acid Metabolism
THESES IN PROGRESS
(Clinical Pharmacology and Therapeutics) PhD Theses in Progress
N. CHRISTOPHIDIS - Pharmacokinetics of Cytotoxic Drugs
E. L. CONWAY — Interactions ofa-methyldopa with Aminergic Pathways in the Central Nervous System A. CULVENOR — The Subcellular Distribution and Regulation of Noradrenaline Synthesising Enzymes J. J. McNEIL — Clinical and Pharmacokinetic Studies of Beta Blockers
A. McQUEEN — The effects of Serotonin on Blood Pressure and Social Dominance in Rats P. MIACH — Sympathetic Nervous Activity in Renal Hypertension
G. M1HALY — Clinical Pharmacology of Anticonvulsants
MSc (Prelim) Thesis in Progress O. H. O. DRUMMER - Studies ofthe Metabolism of Anti-epileptic Drugs
S U B S T A N T I A L G R A N T S R E C E I V E D Grants have been received as follows: —
National Heart Foundation: Role of Central Nervous System Transmitters and Blood Pressure Regulation National Heart Foundation: Control of Aldosterone Secretion from Isolated Zona Glomcrulosa Cells.
National Heart Foundation: Specific Labelling and Isolation of Cardiac Beta Adreno-receptors using Radioactive Photo-affinity Agents.
National Heart Foundation: Renal Response to Aldosterone.
National Health and Medical Research Council: The Significance of Brain Adrenaline and its Role in Blood Pressure and Hypertension.
National Health and Medical Research Council: Investigation ofthe Local Role ofthe Renin Angiotensin System in thc Kidney.
National Health and Medical Research Council: The Structural and Functional Variation in the Surface Lymphocyte and Tumour Cells.
National Health and Medical Research Council: Modulation of Cellular Cyclic AMP Response by Thyroid Hormones.
National Health and Medical Research Council: The Mucoid Celts in the Gastric Mucosa: Their Role in Gastric Physiology and Pathophysiology.
National Health and Medical Research Council: Vascular Cyclic AMP and Blood Pressure Regulation.
National Health and Medical Research Council: Transport and Excretory Function of the Foetal Liver.
National Health and Medical Research Council: Bile Acid Transport. Its Relationship to Bile Acid Structure and Biliary Lipid Composition.
National Health- and Medical Research Council: A Physiological Study of Attachment.
Anti-Cancer Council of Victoria: The Detection of Ia Antigens and their Relevance to Cancer in Man.
Anti-Cancer Council of Victoria: Pharmacokinetics of Anti-Cancer Drugs.
Life Insurance Fund of Australia and New Zealand: Structure Activity Relationship of Beta Adreno-receptor Drugs and the Relationship of Alterations of Beta Adreno-receptors to Disease States.
Life Insurance Fund of Australia and New- Zealand: Genetic and Functional Studies of the Receptors for Catecholamines in the Mouse.
Tobacco Research Foundation of Australia: The Production of Ia Antigcnetic Specifications on Exposure to Tobacco Smoke in Mouse and Man.
Tobacco Research Foundation of Australia: Aspects of Central Nervous System Function as it Relates to
Australian Kidney Foundation: Investigation ofthe Local Role of the Renin-Angiotensin System in the Kidney.
The Clive and Vera Ramaciotti Foundations: Comparative Ultrastructural and Function Studies of the Gastric Mucosa.
National Institutes of Health: Studies of la Antigenic Specifications in Mouse and Man.
MEDICINE
D E P A R T M E N T O F T H E J A M E S S T E W A R T PROFESSOR.
T H E R O Y A L M E L B O U R N E H O S P I T A L Chairman of department: Professor R. R. H. Lovell Professor RICHARD ROBERT HAYNES LOVELL
Professor PRISCILLA SHEATH KINCAID-SMITH*
First Assistant, Assistant Director and Reader JOSEPH ROBERT EMMOTT FRASER First Assistants and Readers ROGER AZIZ MELICK
KENNETH DAVID MUIRDEN
First Assistant (Clinical Pharmacology) JOHN SHAW
First Assistant (Clinical Epidemiology) DAVID GORDON STUART CHRISTIE Second Assistant (Temporary) ROBERT FRANCIS WESTLAND MOULDS Third Assistant ANTHONY LAWRENCE CUNNINGHAM
NH & MRC Research Fellow JOHN DUNCAN MATHEWS NH & MRC Fellow in Rheumatology BARRY JAMES CLARRIS NH & MRC Senior Research Officer ELSMAREE BAXTER NH & MRC Postgraduate Research Scholars MARIO DE LUISE
LINUS DZIUKAS
JOHN DACRE FOUNTAYNE ENGLAND (to 14.2.77) Postgraduate Medical Research Scholar ANDREW SU PING HUA Commonwealth Scholar CHOI KIT YEUNG
Research Student JOHN DAVID HOBSON Graduate Research Assistants STELLA CLARK
DOUGLAS BIRCH
ROLF ALEXANDER JAUERNIG SHARON LEE JOHNSON
ILEENE MARGARET MACDONALD HELEN LOUISE PHILLIPS KAYLENE JOY QUELCH ANDREW D A M I A N ROBINSON CHRISTOPHER WESTON SLEE SIEW K I M TAY
JANETTE ROSE TEMPERLEY ROBIN LOIS THATCHER
Professorial Associates KENNETH FAIRBAIRN FAIRLEY THOMAS HENRY HURLEY
IAN REAY MACKAY
FRANK I A N RUSSELL M A R T I N